Expresión de búsqueda:
SUPPRESSOR OF CYTOKINE SIGNALING 3 PROTEIN
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DeCS
Descriptor
Inglés
:
Suppressor of Cytokine Signaling 3 Protein
Descriptor
Español
:
Proteína 3 Supresora de la Señalización de Citocinas
Descriptor
Portugués
:
Proteína 3 Supressora da Sinalização de Citocinas
Sinónimos
Inglés
:
SOCS3 Protein
Suppressor of Cytokine Signaling Protein 3
Protein, SOCS3
Categoría:
D12.644.360.024.374.750
D12.776.157.057.249.750
D12.776.476.024.437.750
Definición
Inglés
:
A suppressor of cytokine signaling protein that consists of an N-terminal kinase-inhibitory region, a central SH2 DOMAIN, a characteristic C-terminal SOCS box (a 40-amino acid motif, which functions to recruit E3
UBIQUITIN-PROTEIN LIGASE COMPLEXES
). SOCS3 inhibits cytokine signaling by binding to
RECEPTOR PROTEIN-TYROSINE KINASES
as well as
CYTOKINE RECEPTOR GP130
;
ERYTHROPOIETIN
RECEPTORS;
INSULIN
RECEPTOR; and the
LEPTIN
RECEPTOR. Its functions include
suppression
of
ERYTHROPOIESIS
in the fetal liver.
Nota Histórica
Inglés
:
2017
Calificadores Permitidos
Inglés
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Número del Registro:
56544
Identificador Único:
D000071223
Ocurrencia en la BVS
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS